Modification of plant nitrogen fixation
植物固氮改造

Project Profile 项目简介

By employing AI-driven strategies for nitrogenase design and optimization, we aim to construct novel nitrogen fixation systems with the goal of enabling nitrogen fixation in eukaryotic cells and non-leguminous plants. This work explores the rational engineering of nitrogenase components to function in complex intracellular environments, laying the foundation for self-sufficient nitrogen assimilation in plants (Liu et al., Trends in Biotechnology, 2025; Liu et al., Trends in Plant Science, 2024).

基于AI驱动的的固氮酶设计和改造，构建新型固氮系统，尝试实现真核细胞和非豆科植物固氮 （Liu et al. 2025 Trends in biotechnology, Liu et al. 2024 Trends in plant science）

代表性成果

Liu F., Zhao Z., Fernie A.R. & Zhang Y. (2025). Towards Establishing Functional Nitrogenase Activities within Plants Including Those for Text and Data Mining, Ai Training, and Similar Technologies. Trends in biotechnology opinion

Zhao Z, Fernie A. R. & Zhang Y. (2025). Engineering Nitrogen and Carbon Fixation for Next- Generation Plants. Current Opinion in Plant Biology 85:102699.

Liu F., Fernie A. R. & Zhang Y. J. (2024). Can a Nitrogen-Fixing Organelle Be Engineered within Plants? Trends Plant Sci 29(11): 1168-1171.

Project Figure 项目图